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KMID : 0960920020010010034
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Dementia and Neurocognitive Disorders
2002 Volume.1 No. 1 p.34 ~ p.38
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Apolipoprotein Eε4 allele frequency in Korean Patients with Vascular Dementia
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Kang Hyun-Uk
Park Mee-Young
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Abstract
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Background: The clinical significance of the apolipoprotein E(Apo E)ε4 allele in vascular dementia(VaD) has been a subject of debate. VaD is the most common subtype of dementia in Korean population. Apo E allele frequencies were evaluated in Korean patients with VaD diagnosed by the Erkinjuntti criteria of subcortical vascular dementia and mini-mental-state examination(MMSE) in this study.
Methods: Forty patients participated in the study: 20 patients with VaD and 20 controls with no risk factors for stroke who had absolutely normal brain MRI finding. The Apo E genotype was determined by the polymerase chain reaction(PCR) and allele specific hybridization using the Apo E typing test kit.
Results: The Apo Eε4 allele frequency in the VaD group was 20% and was not significantly different from those of normal controls(15%). The severity of dementia assessed by K-MMSE was not defferent between the VaD patients with Apo Eε4 allele and the VaD patients without Apo Eε4 allele.
Conclusion: These results did not show neither increased frequency of Apo Eε4 allele in Korean VaD patients, nor any differences in trends compared to control subjects.
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KEYWORD
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Vascular dementia, Apolipoproteins E, Erkinjuntti criteria of subcortical vascular dementia
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